PUBLICATIONS Yunching Chen (陳韻晶)†
, Yu-Cheng Su (蘇昱誠)†
& Steve R. Roffler* (2025). Polyethylene glycol immunogenicity in nanomedicine . Nature Reviews Bioengineering . doi.org/10.1038/s44222-025-00321-6. († contributed equally to this work)
Jun-Lun Meng#, Zi-Xuan Dong#, Yan-Ru Chen#, Meng-Hsuan Lin, Yu-Ching
Liu, Steve R. Roffler, Wen-Wei Lin, Chin-Yuan Chang, Shey-Cherng Tzou, TianLu Cheng, Hsiao-Chen Huang, Zhi-Qin Li, Yen-Cheng Lin, and Yu-Cheng Su *
(2025). pH-Responsive Polyethylene Glycol Engagers for Enhanced Brain
Delivery of PEGylated Nanomedicine to Treat Glioblastoma . ACS Nano . doi.org/10.1021/acsnano.4c05906. (IF = 15.8)
Chiao-Yu Hsiao, Jun-Lun Meng, Jung-Zhe Hong, Xuan-Huong Ly, Meng-Hsuan Lin, Chin-Yuan Chang, Minh-Tram T. Nguyen, Tian-Lu Cheng, Wen-Wei Lin, Pierre-Alain Burnouf, Talal Salem Al-Qaisi, En-Shuo Liu, and Yu-Cheng Su *. (2022). Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules . Bioconjugate Chemistry . doi.org/10.1021/acs.bioconjchem.2c00416. (IF = 6.069)
Pierre-Alain Burnouf*
, Steve R. Roffler, Chia-Ching Wu, Yu-Cheng Su . (2022). Glucuronides: From biological waste to bio-nanomedical applications. Journal of Controlled Release . 349: 765-782. (IF = 11.467)
Minh-Tram T. Nguyen, Yu-Chien Shih, Meng-Hsuan Lin, Steve R. Roffler, Chiao-Yu Hsiao, Tian-Lu Cheng, Wen-Wei Lin, En-Chi Lin, Yuh-Jyh Jong, Chin-Yuan Chang* & Yu-Cheng Su *. (2022). Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group. Communications Chemistry . 5: 88. (IF = 7.211)
Kai-Wen Ho, I.-J.u Chen, Yi-An Cheng, Tzu-Yi Liao, En-Shuo Liu, Huei-Jen Chen, Yun-Chi Lu, Yu-Cheng Su , Steve R. Roffler, Bo-Cheng Huang, Hui-Ju Liu, Ming-Yii Huang, Chiao-Yun Chen & Tian-Lu Cheng*
. (2021). Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity. Journal of Nanobiotechnology . 19: 16. (IF=9.429) Even Chen, Bing-Mae Chen, Yu-Cheng Su , Yuan-Chih Chang, Tian-Lu Cheng, Yechezekel Barenholz*, and Steve R. Roffler*. (2020). Premature drug release from polyethylene glycol (PEG)-coated liposomal doxorubicin via formation of the membrane attack complex . ACS Nano . 14: 7808-7822
. (IF= 18.027) Chen IJ, Cheng YA, Ho KW, Lin WW, Cheng KW, Lu YC, Hsieh YC, Huang CC, Chuang CH, Chen FM, Su YC , Roffler SR, Cheng TL*. (2020). Bispecific Antibody (HER2 × mPEG) Enhances Anti-Cancer Effects by Precise Targeting and Accumulation of mPEGylated Liposomes. Acta Biomaterialia . S1742-7061(20)30226-9. (IF= 10.633
) Lee CC*† , Su YC † , Ko TP† , Lin LL, Yang CY, Chang SC, Roffler SR* , Wang HJ*. (2020). Structural basis of polyethylene glycol recognition by antibody. Journal of Biomedical Science . 27(1):12. († contributed equally to this work. IF= 12.771) Cheng YA, Chen IJ, Su YC , Cheng KW, Lu YC, Lin WW, Hsieh YC, Kao CH, Chen FM, Roffler SR*
, Cheng TL*. (2019). Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer . Biomaterials Science . 7: 3404-3417. (IF=7.59) Chen YJ, Chen M, Hsieh YC, Su YC , Wang CH, Cheng CM, Kao AP, Wang KH, Cheng JJ, Chuang KH*. Development of a highly sensitive enzyme-linked immunosorbent assay (ELISA) through use of poly-protein G-expressing cell-based microplates. Scientific Reports . 8: 17868. (IF = 4.122, Rank = 12/64, 18.75%) Al-Qaisi TS, Su YC ,
Roffler SR*. (2018). Transient AID expression for in situ mutagenesis with
improved cellular fitness. Scientific
Reports . 8: 9413. (IF = 4.122, Rank = 12/64, 18.75%) Burnouf
PA, Leu YL, Su
YC , Wu K, Wei-Chi Lin, Roffler SR*. (2018). Reversible glycosidic switch for secure delivery of molecular nanocargos. Nature
Communications . 9:1843 (IF = 12.353,
Rank =3/64, 4.68%) Chen
BM, Al-Aghbar MA, Lee CH, Chang TC, Su YC , Li YC, Chang SE, Chen CC, Chung TH,
Liao YC, Lee CH, Roffler SR. (2017). The Affinity of Elongated
Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering. Frontiers in Immunology . 8:793. (IF = 5.511, Rank =30/155, 19.35%) Chang
CJ, Chen CH, Chen BM, Su YC , Chen YT, Hershfield MS, Lee MT, Chen YT,
Roffler SR* and Wu JY*. (2017). A genome-wide association study identifies a
novel susceptibility locus for the immunogenicity of polyethylene glycol . Nature
Communications . 8:522. (IF = 12.353,
Rank =3/64, 4.68%) Su YC , Burnouf PA, Chuang KH,
Chen BM, Cheng TL, Roffler SR. (2017). Conditional internalization of PEGylated
nanomedicines by PEG engagers for triple negative breast cancer therapy. Nature
Communications . 8:15507. (IF = 12.353,
Rank =3/64, 4.68%)Hao WR, Chen M, Chen YJ, Su YC , Cheng CM, Hsueh HY , Kao
AP, Hsieh YC, Chang Johny, Tseng MY, Chuang KH. (2017). Poly-protein
G-expressing bacteria enhance the sensitivity of immunoassays . Scientific
Reports . 7: 989. (IF = 4.122, Rank = 12/64, 18.75%) Chen
BM, Su YC ,
Chang CJ, Burnouf PA, Chuang KH, Chen CH, Cheng TL, Chen YT, Wu JY, Roffler SR.
(2016). Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene
Glycol in Healthy Individuals . Analytical Chemistry .
88:10661-66. (IF = 6.042, Rank = 4/80, 5%) Huang
WC, Burnouf PA, Su YC , Chen BM, Chuang KH, Lee CW, Wei PK, Cheng TL, and
Roffler SR. (2016). Engineering Chimeric Receptors To Investigate the Size- and
Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells. ACS
Nano . 10:648-62 (IF = 13.709, Rank =
10/171, 5.84%) Tung
HY, Su YC ,
Chen BM, Burnouf PA, Huang WC, Chuang KH, Yan YT, Cheng TL, Roffler SR. (2015).
Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid
Antibodies. Molecular Cancer Therapeutics . 14:1317-26. (IF = 5.365, Rank = 42/222, 18.9%) Su YC , Al-Qaisi TS, Tung HY,
Cheng TL, Chuang KH, Chen BM, Roffler SR. (2014). Mimicking the germinal center
reaction in hybridoma cells to isolate temperature-selective anti-PEG
antibodies. mAbs . 6:1069-83. (IF = 5.165,
Rank = 18/133, 13.53%)Su YC , Cheng TC, Leu YL,
Roffler SR, Wang JY, Chuang CH, Kao CH, Chen KC, Wang HE, Cheng TL. (2014). PET
imaging of β-glucuronidase activity by an activity-based 124I-trapping
probe for the personalized glucuronide prodrug targeted therapy . Molecular
Cancer Therapeutics . 13: 2852-2863. (IF = 5.365,
Rank = 42/222, 18.9%)Cheng
TC, Chuang KH, Chen M, Wang HE, Tzou SC, Su YC , Chuang CH, Kao CH, Chen BM, Chang LS,
Roffler SR, Cheng TL. (2013) Sensitivity of PEGylated interferon detection by
anti-polyethylene glycol (PEG) antibodies depends on PEG length. Bioconjugate
chemistry . 24: 1408-13. (IF = 4.485,
Rank = 10/79, 12.65%) Cheng
TC, Roffler SR, Tzou SC, Chuang KH, Su YC , Chuang CH, Kao CH, Chen CS, Harn IH,
Liu KY, Cheng TL, Leu YL. (2012). An activity-based near-infrared glucuronide
trapping probe for imaging β-glucuronidase expression in deep tissues. Journal
of the American Chemical Society . 134:3103-3110. (IF = 14.357, Rank = 8/171, 4.67%) Su YC , Chen BM, Chuang KH,
Cheng TL, Roffler SR. (2010). Sensitive quantification of PEGylated compounds
by second-generation anti-poly(ethylene glycol) monoclonal antibodies. Bioconjugate
chemistry . 21:1264-1270. (IF = 4.485, Rank = 10/79, 12.65%)Tzou
SC, Roffler SR, Chuang KH, Yeh HP, Kao CH, Su YC , Cheng CM, Tseng WL, Shiea J, Harm IH,
Cheng KW, Chen BM, Hwang JJ, Cheng TL, Wang HE. (2009). Micro-PET imaging of beta-glucuronidase
activity by the hydrophobic conversion of a glucuronide probe. Radiology .
16:83-90. (IF = 7.296, Rank
= 2/126, 1.58%) Cheng
CM, Chu PY, Chuang KH, Roffler SR, Kao CH, Tseng WL, Shiea J, Chang WD, Su YC ,
Chen BM, Wang YM, Cheng TL. (2009). Hapten-derivatized nanoparticle targeting
and imaging of gene expression by multimodality imaging systems. Cancer
Gene Therapy . 16:83-90. (IF = 4.044,
Rank = 27/160, 16.87%) Cheng
CM, Lu YL, Chuang KH, Hung WC, Shiea J, Su YC , Kao CH, Chen BM, Roffler SR, Cheng TL.
(2008). Tumor-targeting prodrug-activating bacteria for cancer therapy. Cancer
Gene Therapy . 15:393-401. (IF = 3.652,
Rank = 38/158, 24%) Su YC , Chuang KH, Wang YM,
Cheng CM, Lin SR, Wang JY, Hwang JJ, Chen BM, Chen KC, Roffler SR, Cheng TL.
(2007). Gene expression imaging by enzymatic catalysis of a fluorescent probe
via membrane-anchored β-glucuronidase . Gene Therapy . 14:565-574. (IF = 3.203, Rank = 48/160, 30%)Chuang
KH, Cheng CM, Roffler SR, Lu YL, Lin SR, Wang JY, Tzou WS, Su YC , Chen BM, Cheng TL.
(2006). Combination cancer therapy by hapten-targeted prodrug-activating
enzymes and cytokines. Bioconjugate chemistry .
17:707-714. (IF = 4.485, Rank = 10/79, 12.65%)